Research Associate

Cloverleaf Bio

Cloverleaf Bio

New Haven, CT, USA
Posted on Thursday, June 6, 2024

About Us

Cloverleaf Bio is an early-stage therapeutics company that is developing a new class of engineered tRNA therapeutics. Our tRNAs target an underappreciated vulnerability of cancer: addiction to high levels of tRNA modifying enzymes. Cloverleaf’s approach to drugging tRNA modifying enzymes uses engineered “trojan horse” tRNAs to modulate translation in cancerous cells. The programmability, potency, and specificity of our tRNAs gives us the potential to dramatically improve cancer treatment.

The Job

We are seeking a Research Associate to join our team. In this position, you will work in close conjunction with our founding team in the creation and development of a completely novel family of RNA therapeutics.

Your responsibilities will range from designing and executing experiments independently and in collaboration with team members, preparation, and handling of RNAs and cell cultures, performing advanced laboratory techniques and methodologies, analyzing data and maintaining excellent written documentation of experiments (e.g. electronic lab notebook).

About You

Excited by the science. We are excited by how science can improve the world and are looking for people who are too.

Flexible. We wear many different hats and are looking for people who are willing to do whatever it takes to pitch in and get the job done.

Resilient. Working in an early-stage startup can be hard. Science is hard. We are looking for people who have a demonstrated track record of sticking with complex problems for the long haul.

Cooperative. As a small team, communication and collaboration are key. We are looking for people who thrive working both independently and collaboratively.


  • BS/BA in biology or related field.
  • Strong problem-solving skills.
  • Ability to work independently.
  • Experience with standard molecular biology techniques, including but not limited to, RNA/DNA extraction, PCR, RT-PCR, qPCR, western blotting, etc.
  • Skilled in mammalian cell culture, passaging/seeding cells, etc.

Nice to haves:

  • 1+ years of post-degree wet lab experience
  • Research experience in tRNA, RNA biology and/or RNA modifications field.
  • Prior experience with data analysis software (e.g. Prism) and statistics.
  • Experience with mammalian cell line engineering (e.g. lentivirus, CRISPR-CAS)


  • Competitive salary commensurate with experience and strong equity incentives.
  • Medical, dental, and vision coverage.
  • Brand new lab space in BioLabs New Haven in downtown New Haven, close to the Yale Shuttle, I-95/91 and Metro North.
  • We will provide a stimulating, collegial, and fast-paced environment. If you are interested in joining our team, then we are excited to hear from you! Please submit resumes at